Edoxaban should be reduced when CrCl is in which range?

• A. 15-50 mL/min
• B. <15 mL/min
• C. >95 mL/min
• D. 10-14 mL/min

Answer: (A)

Edoxaban dosing is adjusted based on kidney function because the drug is partly cleared by the kidneys. When CrCl is in the 15–50 mL/min range, reduced renal clearance leads to higher drug exposure at the standard dose, which increases bleeding risk. Therefore the dose is lowered to 30 mg daily in this range (and further reductions or cautions apply if other factors like body weight ≤60 kg or P-gp inhibitors are present). In CrCl <15 mL/min the drug is not recommended, and in CrCl >95 mL/min use is avoided due to reduced efficacy.