Fondaparinux should be avoided when CrCl is below what value?

• A. 30 mL/min
• B. 50 mL/min
• C. 60 mL/min
• D. 15 mL/min

Answer: (A)

Fondaparinux is cleared by the kidneys, so when creatinine clearance drops, the drug can accumulate and markedly raise the risk of major bleeding. This is why the Beers Criteria advises avoiding fondaparinux when CrCl is under 30 mL/min. If CrCl is above 30 mL/min, use may be considered with caution and close monitoring, but below that threshold, safer alternatives such as unfractionated heparin are typically preferred.