In patients with CrCl less than 30 mL/min, which drug should be avoided due to risks of pulmonary toxicity, hepatotoxicity, and peripheral neuropathy with long-term use?

Study for the AGS Beers Criteria Test. Prepare with flashcards and multiple choice questions, each with hints and explanations. Get ready for your exam with comprehensive resources!

Multiple Choice

In patients with CrCl less than 30 mL/min, which drug should be avoided due to risks of pulmonary toxicity, hepatotoxicity, and peripheral neuropathy with long-term use?

Nitrofurantoin should be avoided when kidney function is reduced (CrCl <30 mL/min) because it shifts from being primarily urinary to becoming systemically exposed. With long-term use, this systemic exposure can lead to serious toxicities in multiple organs: pulmonary toxicity (including interstitial pneumonitis and fibrosis), hepatotoxicity, and peripheral neuropathy. Because of these risks, nitrofurantoin is avoided in patients with CrCl below 30 mL/min, especially for extended or preventive courses. The other drugs listed do not carry this same pattern of serious pulmonary, hepatic, and neurologic toxicity tied to reduced renal function, so they are not the best fit for this scenario.

In patients with CrCl less than 30 mL/min, which drug should be avoided due to risks of pulmonary toxicity, hepatotoxicity, and peripheral neuropathy with long-term use?

Study for the AGS Beers Criteria Test. Prepare with flashcards and multiple choice questions, each with hints and explanations. Get ready for your exam with comprehensive resources!

In patients with CrCl less than 30 mL/min, which drug should be avoided due to risks of pulmonary toxicity, hepatotoxicity, and peripheral neuropathy with long-term use?

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