Which antiemetic is listed as having strong anticholinergic properties?

• A. Prochlorperazine
• B. Metoclopramide
• C. Ondansetron
• D. Dolasetron

Answer: (A)

Prochlorperazine stands out because it’s a phenothiazine antiemetic with potent antimuscarinic (anticholinergic) activity. That anticholinergic action underlies dry mouth, constipation, blurred vision, and urinary retention, which are more pronounced with this drug than with the others listed. Metoclopramide mainly blocks dopamine D2 receptors and has some prokinetic effects, but not strong anticholinergic activity. Ondansetron and dolasetron are 5-HT3 receptor antagonists with minimal anticholinergic effects. So prochlorperazine is the antiemetic with strong anticholinergic properties.