Which medication should be avoided when CrCl < 30 mL/min because it increases GI adverse events?

Study for the AGS Beers Criteria Test. Prepare with flashcards and multiple choice questions, each with hints and explanations. Get ready for your exam with comprehensive resources!

Multiple Choice

Which medication should be avoided when CrCl < 30 mL/min because it increases GI adverse events?

When kidney function falls to CrCl below 30 mL/min, certain drugs accumulate and raise the risk of adverse effects. Duloxetine is an SNRI that is largely metabolized by the liver, but its metabolites are cleared by the kidneys. In severe renal impairment, duloxetine exposure increases, which heightens the likelihood of gastrointestinal side effects such as nausea, vomiting, and dyspepsia. That is why the Beers Criteria recommends avoiding duloxetine when CrCl is less than 30 mL/min. The other drugs listed either require dose adjustments rather than outright avoidance at this level of kidney function or carry different risk profiles that aren’t focused on GI adverse events to the same extent in this context.

Which medication should be avoided when CrCl < 30 mL/min because it increases GI adverse events?

Study for the AGS Beers Criteria Test. Prepare with flashcards and multiple choice questions, each with hints and explanations. Get ready for your exam with comprehensive resources!

Which medication should be avoided when CrCl < 30 mL/min because it increases GI adverse events?

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