Which of the following is an antispasmodic with strong anticholinergic properties?

• A. Dicyclomine
• B. Oxybutynin
• C. Tolterodine
• D. Cyclobenzaprine

Answer: (A)

The main idea is identifying an antispasmodic that also has strong anticholinergic effects, meaning it blocks muscarinic receptors to relax smooth muscle and reduce secretions in the gut.

Dicyclomine fits this best because it acts as a competitive muscarinic antagonist in the gastrointestinal tract, effectively reducing smooth muscle spasms and cramps associated with conditions like irritable bowel syndrome. Its potent anticholinergic action explains the common dry mouth, constipation, blurred vision, and urinary retention you’ll see with this drug. This combination of GI antispasmodic effect plus strong anticholinergic activity is what makes it the correct choice.

Oxybutynin and tolterodine are also muscarinic antagonists with anticholinergic effects, but they are primarily used for bladder overactivity rather than GI spasm. Cyclobenzaprine is a central muscle relaxant with some anticholinergic properties, but it’s not classified as a GI antispasmodic with strong anticholinergic action.